Drug interactions
Chloramphenicol + Nisoldipine
Severity: Major
Chloramphenicol and Nisoldipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nisoldipine undergoes extensive CYP3A4 first-pass metabolism, so inhibitors can greatly raise its levels. This can cause marked hypotension, peripheral edema and reflex tachycardia.
What this interaction means in plain words
Chloramphenicol and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Nisoldipine belongs to Cardiovascular.
Why it happens
Chloramphenicol inhibits intestinal and hepatic CYP3A4, decreasing nisoldipine first-pass metabolism.
What to do
Avoid if possible and use another antibiotic or a calcium channel blocker less dependent on CYP3A4. If combined, monitor blood pressure closely and reduce the nisoldipine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chloramphenicol
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
- Cyclosporin + Nisoldipine Major
Frequently asked questions
Can I take Chloramphenicol with Nisoldipine?
MediHelp rates the interaction as major. Chloramphenicol and Nisoldipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nisoldipine undergoes extensive CYP3A4 first-pass metabolism, so inhibitors can greatly raise its levels. This can cause marked hypotension, peripheral edema and reflex tachycardia.
How serious is the interaction between Chloramphenicol and Nisoldipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use another antibiotic or a calcium channel blocker less dependent on CYP3A4. If combined, monitor blood pressure closely and reduce the nisoldipine dose.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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