Drug interactions
Itraconazole + Nisoldipine
Severity: Contraindicated
Itraconazole and Nisoldipine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole substantially increases nisoldipine exposure, which can cause profound hypotension, peripheral edema and reflex tachycardia. Itraconazole itself has negative inotropic effects, so heart failure risk is also increased.
What this interaction means in plain words
Itraconazole and Nisoldipine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Nisoldipine belongs to Cardiovascular.
Why it happens
Itraconazole strongly inhibits CYP3A4-mediated first-pass and systemic metabolism of nisoldipine, with additive negative inotropy.
What to do
Avoid the combination during itraconazole therapy and for about 2 weeks after it ends; choose an antihypertensive not metabolized by CYP3A4 or an alternative antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Nisoldipine
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
- Cyclosporin + Nisoldipine Major
Frequently asked questions
Can I take Itraconazole with Nisoldipine?
MediHelp rates the interaction as contraindicated. Itraconazole and Nisoldipine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole substantially increases nisoldipine exposure, which can cause profound hypotension, peripheral edema and reflex tachycardia. Itraconazole itself has negative inotropic effects, so heart failure risk is also increased.
How serious is the interaction between Itraconazole and Nisoldipine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination during itraconazole therapy and for about 2 weeks after it ends; choose an antihypertensive not metabolized by CYP3A4 or an alternative antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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