Drug interactions
Bethanechol + Dosulepin
Severity: Moderate
Bethanechol and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with anticholinergic effects that can reduce the response to bethanechol and contribute to urinary retention.
What this interaction means in plain words
Bethanechol and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Dosulepin belongs to Central Nervous System.
Why it happens
Anticholinergic muscarinic blockade opposes bethanechol's agonist action.
What to do
Monitor urinary function and bethanechol effect; consider a less anticholinergic antidepressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Bethanechol with Dosulepin?
MediHelp rates the interaction as moderate. Bethanechol and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with anticholinergic effects that can reduce the response to bethanechol and contribute to urinary retention.
How serious is the interaction between Bethanechol and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary function and bethanechol effect; consider a less anticholinergic antidepressant.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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