Drug interactions
Bethanechol + Scopolamine
Severity: Moderate
Bethanechol and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scopolamine is a muscarinic antagonist and directly opposes the muscarinic agonist action of bethanechol. Each drug can blunt the therapeutic effect of the other, for example reducing bethanechol-induced bladder contraction.
What this interaction means in plain words
Bethanechol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Scopolamine belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid combining when bethanechol is given to stimulate bladder or gut motility; if both are needed, monitor voiding or bowel response and reassess the need for the anticholinergic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Scopolamine
Frequently asked questions
Can I take Bethanechol with Scopolamine?
MediHelp rates the interaction as moderate. Bethanechol and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Scopolamine is a muscarinic antagonist and directly opposes the muscarinic agonist action of bethanechol. Each drug can blunt the therapeutic effect of the other, for example reducing bethanechol-induced bladder contraction.
How serious is the interaction between Bethanechol and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when bethanechol is given to stimulate bladder or gut motility; if both are needed, monitor voiding or bowel response and reassess the need for the anticholinergic.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
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