Drug interactions
Bethanechol + Tolterodine
Severity: Moderate
Bethanechol and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolterodine is a muscarinic antagonist that opposes the bladder-stimulating effect of bethanechol. Using both reduces the benefit of each and makes the clinical result unpredictable.
What this interaction means in plain words
Bethanechol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bethanechol belongs to Gastrointestinal Tract; Tolterodine belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Avoid combining these drugs when possible; if used together, monitor bladder emptying and symptom control and reassess the regimen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bethanechol and Tolterodine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bethanechol
- Bethanechol + Darifenacin Major
- Bethanechol + Fesoterodine Major
- Bethanechol + Oxybutynin Major
- Bethanechol + Physostigmine Major
- Amifampridine + Bethanechol Moderate
- Amitriptyline + Bethanechol Moderate
Other interactions of Tolterodine
Frequently asked questions
Can I take Bethanechol with Tolterodine?
MediHelp rates the interaction as moderate. Bethanechol and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolterodine is a muscarinic antagonist that opposes the bladder-stimulating effect of bethanechol. Using both reduces the benefit of each and makes the clinical result unpredictable.
How serious is the interaction between Bethanechol and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining these drugs when possible; if used together, monitor bladder emptying and symptom control and reassess the regimen.
What other medicines interact with Bethanechol?
MediHelp also lists interactions of Bethanechol with, for example, Darifenacin, Fesoterodine, Oxybutynin. The full list is on the Bethanechol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
