Drug interactions
Betrixaban + Clarithromycin
Severity: Moderate
Betrixaban and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits P-glycoprotein and raises betrixaban exposure. Higher betrixaban levels increase the risk of bleeding.
What this interaction means in plain words
Betrixaban and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux of betrixaban by clarithromycin increases its absorption and reduces its clearance.
What to do
Reduce betrixaban to the labeled P-gp inhibitor regimen (80 mg once, then 40 mg daily). Monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Betrixaban with Clarithromycin?
MediHelp rates the interaction as moderate. Betrixaban and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin inhibits P-glycoprotein and raises betrixaban exposure. Higher betrixaban levels increase the risk of bleeding.
How serious is the interaction between Betrixaban and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled P-gp inhibitor regimen (80 mg once, then 40 mg daily). Monitor for signs of bleeding.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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