Drug interactions
Betrixaban + Crizotinib
Severity: Moderate
Betrixaban and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits P-glycoprotein and may increase betrixaban plasma concentrations. Higher betrixaban exposure raises the risk of bleeding.
What this interaction means in plain words
Betrixaban and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Crizotinib inhibits P-gp-mediated efflux of betrixaban, increasing its systemic exposure.
What to do
Reduce betrixaban to the labeled dose for P-gp inhibitors (80 mg once, then 40 mg daily). Monitor for signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Betrixaban with Crizotinib?
MediHelp rates the interaction as moderate. Betrixaban and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits P-glycoprotein and may increase betrixaban plasma concentrations. Higher betrixaban exposure raises the risk of bleeding.
How serious is the interaction between Betrixaban and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to the labeled dose for P-gp inhibitors (80 mg once, then 40 mg daily). Monitor for signs of bleeding.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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