Drug interactions
Betrixaban + Flibanserin
Severity: Moderate
Betrixaban and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin may raise betrixaban concentrations through P-glycoprotein inhibition, increasing anticoagulant exposure and bleeding risk.
What this interaction means in plain words
Betrixaban and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein-mediated efflux increases betrixaban absorption.
What to do
Use the reduced betrixaban dosing recommended for P-gp inhibitors and monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Betrixaban with Flibanserin?
MediHelp rates the interaction as moderate. Betrixaban and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin may raise betrixaban concentrations through P-glycoprotein inhibition, increasing anticoagulant exposure and bleeding risk.
How serious is the interaction between Betrixaban and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the reduced betrixaban dosing recommended for P-gp inhibitors and monitor for bleeding.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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