Drug interactions
Betrixaban + Mefenamic acid
Severity: Major
Betrixaban and Mefenamic acid: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause bleeding, so taking them together increases the risk of gastrointestinal and other hemorrhage. Betrixaban labeling warns about concurrent use of drugs affecting hemostasis, including NSAIDs.
What this interaction means in plain words
Betrixaban and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic effect: factor Xa inhibition combined with NSAID platelet inhibition and gastric mucosal injury.
What to do
Avoid concurrent use where possible and use a non-NSAID analgesic such as paracetamol. If unavoidable, monitor closely for bleeding and check hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Betrixaban with Mefenamic acid?
MediHelp rates the interaction as major. Betrixaban and Mefenamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause bleeding, so taking them together increases the risk of gastrointestinal and other hemorrhage. Betrixaban labeling warns about concurrent use of drugs affecting hemostasis, including NSAIDs.
How serious is the interaction between Betrixaban and Mefenamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and use a non-NSAID analgesic such as paracetamol. If unavoidable, monitor closely for bleeding and check hemoglobin.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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