Drug interactions
Betrixaban + Mefloquine
Severity: Moderate
Betrixaban and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
P-glycoprotein inhibition by mefloquine may raise betrixaban concentrations and increase bleeding risk. Betrixaban labeling recommends a lower dose with P-gp inhibitors.
What this interaction means in plain words
Betrixaban and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-glycoprotein inhibition increases betrixaban absorption and reduces its efflux.
What to do
Reduce betrixaban to 80 mg once followed by 40 mg daily, per labeling. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Betrixaban with Mefloquine?
MediHelp rates the interaction as moderate. Betrixaban and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. P-glycoprotein inhibition by mefloquine may raise betrixaban concentrations and increase bleeding risk. Betrixaban labeling recommends a lower dose with P-gp inhibitors.
How serious is the interaction between Betrixaban and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce betrixaban to 80 mg once followed by 40 mg daily, per labeling. Monitor for bleeding.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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