Drug interactions
Bevacizumab + Doxorubicin
Severity: Moderate
Bevacizumab and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with higher cumulative anthracycline doses or prior cardiac disease.
What this interaction means in plain words
Bevacizumab and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bevacizumab belongs to Oncology; Doxorubicin belongs to Oncology.
Why it happens
Additive cardiotoxicity through anthracycline myocardial injury and VEGF inhibition with associated hypertension.
What to do
Assess baseline left ventricular ejection fraction and repeat periodically during treatment. Control blood pressure and track the cumulative doxorubicin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
- Bevacizumab + Efgartigimod alfa Moderate
Frequently asked questions
Can I take Bevacizumab with Doxorubicin?
MediHelp rates the interaction as moderate. Bevacizumab and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can impair cardiac function, and bevacizumab may add to anthracycline-related heart failure and left ventricular dysfunction. Bevacizumab also causes hypertension, which adds to cardiac strain. The risk is greater with higher cumulative anthracycline doses or prior cardiac disease.
How serious is the interaction between Bevacizumab and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess baseline left ventricular ejection fraction and repeat periodically during treatment. Control blood pressure and track the cumulative doxorubicin dose.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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