Drug interactions
Bevacizumab + Irinotecan liposomal
Severity: Moderate
Bevacizumab and Irinotecan liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause serious gastrointestinal toxicity and bevacizumab may add to the risk of diarrhea, neutropenia and gastrointestinal perforation. The combination is used in practice but needs careful toxicity surveillance.
What this interaction means in plain words
Bevacizumab and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic toxicity; irinotecan causes myelosuppression and diarrhea while bevacizumab adds mucosal and vascular toxicity.
What to do
Monitor blood counts and bowel function and treat diarrhea promptly; reduce irinotecan dose or hold treatment for grade 3-4 toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bevacizumab and Irinotecan liposomal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bevacizumab
- Bevacizumab + Sunitinib Major
- Bevacizumab + Daunorubicin Moderate
- Bevacizumab + Dengue vaccine Moderate
- Bevacizumab + Doxorubicin Moderate
- Bevacizumab + Doxorubicin liposomal Moderate
- Bevacizumab + Efgartigimod / hyaluronidase sc Moderate
Frequently asked questions
Can I take Bevacizumab with Irinotecan liposomal?
MediHelp rates the interaction as moderate. Bevacizumab and Irinotecan liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause serious gastrointestinal toxicity and bevacizumab may add to the risk of diarrhea, neutropenia and gastrointestinal perforation. The combination is used in practice but needs careful toxicity surveillance.
How serious is the interaction between Bevacizumab and Irinotecan liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and bowel function and treat diarrhea promptly; reduce irinotecan dose or hold treatment for grade 3-4 toxicity.
What other medicines interact with Bevacizumab?
MediHelp also lists interactions of Bevacizumab with, for example, Sunitinib, Daunorubicin, Dengue vaccine. The full list is on the Bevacizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
