Drug interactions
Bexagliflozin + Insulin degludec-liraglutide
Severity: Moderate
Bexagliflozin and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexagliflozin lowers blood glucose through urinary glucose excretion, and this adds to the glucose-lowering action of insulin degludec and liraglutide. The combination raises the risk of hypoglycemia, especially when insulin doses have not been reduced.
What this interaction means in plain words
Bexagliflozin and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects from SGLT2 inhibition together with insulin and GLP-1 receptor agonism.
What to do
Consider reducing the insulin dose when starting bexagliflozin and monitor blood glucose more frequently. Also watch for volume depletion and ketoacidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Bexagliflozin and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexagliflozin lowers blood glucose through urinary glucose excretion, and this adds to the glucose-lowering action of insulin degludec and liraglutide. The combination raises the risk of hypoglycemia, especially when insulin doses have not been reduced.
How serious is the interaction between Bexagliflozin and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting bexagliflozin and monitor blood glucose more frequently. Also watch for volume depletion and ketoacidosis.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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