Drug interactions
Bexagliflozin + Insulin glargine-lixisenatide
Severity: Moderate
Bexagliflozin and Insulin glargine-lixisenatide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining bexagliflozin with insulin increases the risk of hypoglycemia. The SGLT2 inhibitor also carries a risk of ketoacidosis in insulin-treated patients.
What this interaction means in plain words
Bexagliflozin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexagliflozin belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Additive glucose lowering, as SGLT2 inhibition promotes urinary glucose excretion independent of insulin.
What to do
Consider reducing the insulin dose when starting bexagliflozin and monitor glucose closely. Avoid over-reducing insulin and watch for ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Bexagliflozin
- Bexagliflozin + Carbamazepine Moderate
- Bexagliflozin + Chlorpropamide Moderate
- Bexagliflozin + Glibenclamide Moderate
- Bexagliflozin + Gliclazide Moderate
- Bexagliflozin + Glimepiride Moderate
- Bexagliflozin + Glimepiride-pioglitazone Moderate
Frequently asked questions
Can I take Bexagliflozin with Insulin glargine-lixisenatide?
MediHelp rates the interaction as moderate. Bexagliflozin and Insulin glargine-lixisenatide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining bexagliflozin with insulin increases the risk of hypoglycemia. The SGLT2 inhibitor also carries a risk of ketoacidosis in insulin-treated patients.
How serious is the interaction between Bexagliflozin and Insulin glargine-lixisenatide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting bexagliflozin and monitor glucose closely. Avoid over-reducing insulin and watch for ketoacidosis symptoms.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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