Drug interactions
Bexarotene + Cimetidine
Severity: Minor
Bexarotene and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene is metabolized in part by CYP3A4, so cimetidine may slightly increase its levels. This could increase bexarotene toxicities such as hypertriglyceridemia, hypothyroidism and liver enzyme elevation.
What this interaction means in plain words
Bexarotene and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bexarotene belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by cimetidine reduces bexarotene metabolism.
What to do
Monitor lipids, thyroid function and liver tests as per routine bexarotene care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Cimetidine?
MediHelp rates the interaction as minor. Bexarotene and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bexarotene is metabolized in part by CYP3A4, so cimetidine may slightly increase its levels. This could increase bexarotene toxicities such as hypertriglyceridemia, hypothyroidism and liver enzyme elevation.
How serious is the interaction between Bexarotene and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipids, thyroid function and liver tests as per routine bexarotene care.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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