Drug interactions
Bexarotene + Lapatinib
Severity: Moderate
Bexarotene and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may increase bexarotene exposure via CYP3A4 inhibition. Higher levels could worsen bexarotene effects such as hypertriglyceridemia, hypothyroidism and pancreatitis.
What this interaction means in plain words
Bexarotene and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4-mediated bexarotene metabolism.
What to do
Monitor lipid profile and thyroid function during coadministration. Reduce the bexarotene dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Lapatinib?
MediHelp rates the interaction as moderate. Bexarotene and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may increase bexarotene exposure via CYP3A4 inhibition. Higher levels could worsen bexarotene effects such as hypertriglyceridemia, hypothyroidism and pancreatitis.
How serious is the interaction between Bexarotene and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid profile and thyroid function during coadministration. Reduce the bexarotene dose if toxicity develops.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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