Drug interactions
Bexarotene + Sitagliptin
Severity: Minor
Bexarotene and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may enhance insulin sensitivity and has been associated with increased effects of insulin-enhancing agents. Combined with sitagliptin, glucose lowering could be increased. Sitagliptin alone rarely causes hypoglycemia, so risk is mainly with additional agents.
What this interaction means in plain words
Bexarotene and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bexarotene belongs to Oncology; Sitagliptin belongs to Endocrine.
Why it happens
Possible additive glucose-lowering effect via insulin sensitization; mechanism is not firmly established.
What to do
Monitor blood glucose when starting bexarotene in patients taking sitagliptin. Reduce concurrent sulfonylurea or insulin doses if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Sitagliptin?
MediHelp rates the interaction as minor. Bexarotene and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bexarotene may enhance insulin sensitivity and has been associated with increased effects of insulin-enhancing agents. Combined with sitagliptin, glucose lowering could be increased. Sitagliptin alone rarely causes hypoglycemia, so risk is mainly with additional agents.
How serious is the interaction between Bexarotene and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting bexarotene in patients taking sitagliptin. Reduce concurrent sulfonylurea or insulin doses if hypoglycemia occurs.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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