Drug interactions
Bexarotene + Tolazamide
Severity: Moderate
Bexarotene and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene may improve insulin sensitivity, which could add to the effect of a sulfonylurea and lead to hypoglycemia. Hypoglycemia is not seen with bexarotene alone, so the risk depends on the sulfonylurea.
What this interaction means in plain words
Bexarotene and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Tolazamide belongs to Endocrine.
Why it happens
Additive glucose lowering through enhanced insulin sensitivity (RXR-mediated).
What to do
Monitor blood glucose when starting bexarotene. Lower the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Tolazamide?
MediHelp rates the interaction as moderate. Bexarotene and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene may improve insulin sensitivity, which could add to the effect of a sulfonylurea and lead to hypoglycemia. Hypoglycemia is not seen with bexarotene alone, so the risk depends on the sulfonylurea.
How serious is the interaction between Bexarotene and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting bexarotene. Lower the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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