Drug interactions
Bexarotene + Warfarin
Severity: Moderate
Bexarotene and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bexarotene induces CYP3A4 and may lower warfarin exposure, potentially reducing anticoagulant effect and INR. This can raise the risk of thromboembolism.
What this interaction means in plain words
Bexarotene and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bexarotene belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Bexarotene induces CYP3A4, increasing metabolism of R-warfarin.
What to do
Monitor INR more frequently when bexarotene is started or stopped and adjust the warfarin dose to maintain the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Bexarotene
- Bexarotene + Gemfibrozil Major
- Bexarotene + Lorlatinib Major
- Alogliptin-pioglitazone + Bexarotene Moderate
- Amobarbital + Bexarotene Moderate
- Aprepitant + Bexarotene Moderate
- Axitinib + Bexarotene Moderate
Frequently asked questions
Can I take Bexarotene with Warfarin?
MediHelp rates the interaction as moderate. Bexarotene and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bexarotene induces CYP3A4 and may lower warfarin exposure, potentially reducing anticoagulant effect and INR. This can raise the risk of thromboembolism.
How serious is the interaction between Bexarotene and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when bexarotene is started or stopped and adjust the warfarin dose to maintain the target range.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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