Drug interactions
Bicalutamide + Cabozantinib
Severity: Minor
Bicalutamide and Cabozantinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib is a CYP3A4 substrate, but bicalutamide is only a weak inhibitor, so any increase in exposure is likely small. Awareness of adverse effects is reasonable.
What this interaction means in plain words
Bicalutamide and Cabozantinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Cabozantinib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may slightly reduce cabozantinib clearance.
What to do
No dose change is needed; monitor for cabozantinib toxicities such as diarrhea, hypertension and hand-foot syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bicalutamide and Cabozantinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Cabozantinib
Frequently asked questions
Can I take Bicalutamide with Cabozantinib?
MediHelp rates the interaction as minor. Bicalutamide and Cabozantinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cabozantinib is a CYP3A4 substrate, but bicalutamide is only a weak inhibitor, so any increase in exposure is likely small. Awareness of adverse effects is reasonable.
How serious is the interaction between Bicalutamide and Cabozantinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for cabozantinib toxicities such as diarrhea, hypertension and hand-foot syndrome.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
