Drug interactions
Bicalutamide + Ivosidenib
Severity: Moderate
Bicalutamide and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 substrate that can prolong the QT interval, and bicalutamide, itself linked to QT effects as an androgen-deprivation agent, could slightly raise levels. Additive QT effects are the main concern.
What this interaction means in plain words
Bicalutamide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bicalutamide belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition plus additive QT prolongation potential.
What to do
Monitor ECG and electrolytes (potassium, magnesium) during co-treatment; reduce or interrupt ivosidenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bicalutamide and Ivosidenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Lonafarnib Moderate
- Bicalutamide + Mavacamten Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Bicalutamide with Ivosidenib?
MediHelp rates the interaction as moderate. Bicalutamide and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 substrate that can prolong the QT interval, and bicalutamide, itself linked to QT effects as an androgen-deprivation agent, could slightly raise levels. Additive QT effects are the main concern.
How serious is the interaction between Bicalutamide and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes (potassium, magnesium) during co-treatment; reduce or interrupt ivosidenib if QTc becomes markedly prolonged.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
