Drug interactions
Bicalutamide + Eliglustat
Severity: Moderate
Bicalutamide and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide may weakly inhibit CYP3A4 and could slightly raise eliglustat exposure. Because eliglustat can prolong PR, QRS and QT intervals, higher levels are a concern, particularly in CYP2D6 poor metabolizers.
What this interaction means in plain words
Bicalutamide and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bicalutamide belongs to Endocrine; Eliglustat belongs to Miscellaneous.
Why it happens
Weak possible CYP3A4 inhibition by bicalutamide reduces eliglustat metabolism.
What to do
Check CYP2D6 status and obtain a baseline ECG; monitor for arrhythmia symptoms and consider eliglustat dose adjustment according to labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
- Bicalutamide + Mavacamten Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Bicalutamide with Eliglustat?
MediHelp rates the interaction as moderate. Bicalutamide and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bicalutamide may weakly inhibit CYP3A4 and could slightly raise eliglustat exposure. Because eliglustat can prolong PR, QRS and QT intervals, higher levels are a concern, particularly in CYP2D6 poor metabolizers.
How serious is the interaction between Bicalutamide and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check CYP2D6 status and obtain a baseline ECG; monitor for arrhythmia symptoms and consider eliglustat dose adjustment according to labeling.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Flibanserin. The full list is on the Bicalutamide page.
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