Drug interactions
Bicalutamide + Cannabidiol
Severity: Minor
Bicalutamide and Cannabidiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is a weak CYP3A4 inhibitor and may slightly increase cannabidiol exposure. Increased sedation or liver enzyme elevation is possible but unlikely to be significant.
What this interaction means in plain words
Bicalutamide and Cannabidiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Cannabidiol belongs to Central Nervous System.
Why it happens
Bicalutamide weakly inhibits CYP3A4, reducing cannabidiol metabolism.
What to do
Monitor for somnolence and liver enzyme elevations. Reduce the cannabidiol dose if adverse effects develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Bicalutamide with Cannabidiol?
MediHelp rates the interaction as minor. Bicalutamide and Cannabidiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is a weak CYP3A4 inhibitor and may slightly increase cannabidiol exposure. Increased sedation or liver enzyme elevation is possible but unlikely to be significant.
How serious is the interaction between Bicalutamide and Cannabidiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence and liver enzyme elevations. Reduce the cannabidiol dose if adverse effects develop.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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