Drug interactions
Bicalutamide + Diazepam intranasal
Severity: Minor
Bicalutamide and Diazepam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam is partly cleared by CYP3A4 and CYP2C19, and bicalutamide may slightly reduce its clearance. Excess sedation is possible but unlikely to be significant.
What this interaction means in plain words
Bicalutamide and Diazepam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may slow diazepam metabolism.
What to do
No adjustment needed; monitor for excessive sedation and respiratory depression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Diazepam intranasal?
MediHelp rates the interaction as minor. Bicalutamide and Diazepam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diazepam is partly cleared by CYP3A4 and CYP2C19, and bicalutamide may slightly reduce its clearance. Excess sedation is possible but unlikely to be significant.
How serious is the interaction between Bicalutamide and Diazepam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; monitor for excessive sedation and respiratory depression.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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