Drug interactions
Bicalutamide + Fentanyl transdermal
Severity: Minor
Bicalutamide and Fentanyl transdermal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide is only a weak CYP3A4 inhibitor, so any rise in fentanyl exposure is expected to be modest. Because transdermal fentanyl has a long, hard-to-reverse exposure, delayed opioid toxicity is still conceivable.
What this interaction means in plain words
Bicalutamide and Fentanyl transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated fentanyl metabolism by bicalutamide.
What to do
Monitor for sedation and respiratory depression after bicalutamide is started or stopped; adjust the fentanyl dose only if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Fentanyl transdermal?
MediHelp rates the interaction as minor. Bicalutamide and Fentanyl transdermal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide is only a weak CYP3A4 inhibitor, so any rise in fentanyl exposure is expected to be modest. Because transdermal fentanyl has a long, hard-to-reverse exposure, delayed opioid toxicity is still conceivable.
How serious is the interaction between Bicalutamide and Fentanyl transdermal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression after bicalutamide is started or stopped; adjust the fentanyl dose only if symptoms occur.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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