Drug interactions
Bicalutamide + Fentanyl
Severity: Minor
Bicalutamide and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bicalutamide shows only weak CYP3A4 inhibition in vitro, and a clinically meaningful rise in fentanyl exposure has not been established. The interaction is mostly theoretical.
What this interaction means in plain words
Bicalutamide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bicalutamide belongs to Endocrine; Fentanyl belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition by bicalutamide reducing fentanyl clearance.
What to do
No dose change is routinely needed; monitor for excess sedation or respiratory depression when starting bicalutamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Fentanyl?
MediHelp rates the interaction as minor. Bicalutamide and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bicalutamide shows only weak CYP3A4 inhibition in vitro, and a clinically meaningful rise in fentanyl exposure has not been established. The interaction is mostly theoretical.
How serious is the interaction between Bicalutamide and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for excess sedation or respiratory depression when starting bicalutamide.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
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