Drug interactions
Bicalutamide + Irinotecan liposomal
Severity: Minor
Bicalutamide and Irinotecan liposomal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irinotecan is activated and cleared in part by CYP3A4, but bicalutamide is only a weak inhibitor. A clinically important change in exposure is not expected.
What this interaction means in plain words
Bicalutamide and Irinotecan liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition may alter irinotecan metabolism slightly.
What to do
No dose adjustment; monitor for neutropenia and diarrhea as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Irinotecan liposomal?
MediHelp rates the interaction as minor. Bicalutamide and Irinotecan liposomal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irinotecan is activated and cleared in part by CYP3A4, but bicalutamide is only a weak inhibitor. A clinically important change in exposure is not expected.
How serious is the interaction between Bicalutamide and Irinotecan liposomal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment; monitor for neutropenia and diarrhea as usual.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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