Drug interactions
Bicalutamide + Midazolam intranasal
Severity: Minor
Bicalutamide and Midazolam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam is cleared by CYP3A4, and bicalutamide inhibits this enzyme only weakly. A small increase in midazolam exposure and mildly prolonged sedation is possible.
What this interaction means in plain words
Bicalutamide and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4-mediated midazolam metabolism by bicalutamide.
What to do
No dose change is generally required; monitor sedation and recovery time after the dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Midazolam intranasal?
MediHelp rates the interaction as minor. Bicalutamide and Midazolam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Midazolam is cleared by CYP3A4, and bicalutamide inhibits this enzyme only weakly. A small increase in midazolam exposure and mildly prolonged sedation is possible.
How serious is the interaction between Bicalutamide and Midazolam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor sedation and recovery time after the dose.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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