Drug interactions
Bicalutamide + Sufentanil sl
Severity: Moderate
Bicalutamide and Sufentanil sl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is cleared by CYP3A4, and strong inhibitors can cause dangerous opioid accumulation. Bicalutamide is only a weak inhibitor, but opioid respiratory depression makes caution reasonable.
What this interaction means in plain words
Bicalutamide and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 inhibition by bicalutamide may reduce sufentanil clearance.
What to do
Monitor for sedation and respiratory depression, especially at initiation; reduce the opioid dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Sufentanil sl?
MediHelp rates the interaction as moderate. Bicalutamide and Sufentanil sl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is cleared by CYP3A4, and strong inhibitors can cause dangerous opioid accumulation. Bicalutamide is only a weak inhibitor, but opioid respiratory depression makes caution reasonable.
How serious is the interaction between Bicalutamide and Sufentanil sl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, especially at initiation; reduce the opioid dose if excessive sedation occurs.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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