Drug interactions
Bicalutamide + Tezacaftor
Severity: Minor
Bicalutamide and Tezacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tezacaftor is a CYP3A substrate and inhibitors raise exposure, which may increase adverse effects such as transaminase elevation. Bicalutamide is a weak inhibitor, so the effect is probably small.
What this interaction means in plain words
Bicalutamide and Tezacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP3A-mediated tezacaftor metabolism by bicalutamide.
What to do
No empirical dose change; monitor liver function and tolerability, which are already needed with both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bicalutamide
- Bicalutamide + Lomitapide Major
- Aminolevulinic acid + Bicalutamide Moderate
- Bicalutamide + Eliglustat Moderate
- Bicalutamide + Flibanserin Moderate
- Bicalutamide + Ivosidenib Moderate
- Bicalutamide + Lonafarnib Moderate
Frequently asked questions
Can I take Bicalutamide with Tezacaftor?
MediHelp rates the interaction as minor. Bicalutamide and Tezacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tezacaftor is a CYP3A substrate and inhibitors raise exposure, which may increase adverse effects such as transaminase elevation. Bicalutamide is a weak inhibitor, so the effect is probably small.
How serious is the interaction between Bicalutamide and Tezacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor liver function and tolerability, which are already needed with both drugs.
What other medicines interact with Bicalutamide?
MediHelp also lists interactions of Bicalutamide with, for example, Lomitapide, Aminolevulinic acid, Eliglustat. The full list is on the Bicalutamide page.
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