Drug interactions
Bictegravir + Calcium carbonate
Severity: Moderate
Bictegravir and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium binds bictegravir in the gut and can lower its absorption when taken fasting. Reduced exposure may impair viral suppression.
What this interaction means in plain words
Bictegravir and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of bictegravir by calcium cations in the gastrointestinal tract reduces absorption.
What to do
Take bictegravir together with calcium supplements only with food; otherwise give bictegravir at least 2 hours before calcium-containing antacids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Frequently asked questions
Can I take Bictegravir with Calcium carbonate?
MediHelp rates the interaction as moderate. Bictegravir and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium binds bictegravir in the gut and can lower its absorption when taken fasting. Reduced exposure may impair viral suppression.
How serious is the interaction between Bictegravir and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take bictegravir together with calcium supplements only with food; otherwise give bictegravir at least 2 hours before calcium-containing antacids.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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