Drug interactions
Bismuth subsalicylate + Sarecycline
Severity: Minor
Bismuth subsalicylate and Sarecycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bismuth can chelate oral sarecycline and reduce absorption, although sarecycline is less affected by cations than older tetracyclines. Reduced exposure could weaken acne treatment response.
What this interaction means in plain words
Bismuth subsalicylate and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Chelation of sarecycline by bismuth cations in the gut reduces absorption.
What to do
Separate doses by at least 2 to 3 hours, giving sarecycline first. Monitor therapeutic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bismuth subsalicylate
- Bismuth subsalicylate + Dichlorphenamide Major
- Bismuth subsalicylate + Warfarin Major
- Acetylsalicylic acid + Bismuth subsalicylate Moderate
- Amlodipine-benazepril + Bismuth subsalicylate Moderate
- Aspirin / citric acid / sodium bicarbonate + Bismuth subsalicylate Moderate
- Aspirin rectal + Bismuth subsalicylate Moderate
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Bismuth subsalicylate with Sarecycline?
MediHelp rates the interaction as minor. Bismuth subsalicylate and Sarecycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bismuth can chelate oral sarecycline and reduce absorption, although sarecycline is less affected by cations than older tetracyclines. Reduced exposure could weaken acne treatment response.
How serious is the interaction between Bismuth subsalicylate and Sarecycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 to 3 hours, giving sarecycline first. Monitor therapeutic response.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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