Drug interactions
Bisoprolol + Calcium gluconate
Severity: Minor
Bisoprolol and Calcium gluconate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous calcium gluconate can transiently counteract the negative inotropic and chronotropic effects of bisoprolol. This is mainly relevant in beta-blocker toxicity, where calcium is used as a treatment.
What this interaction means in plain words
Bisoprolol and Calcium gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bisoprolol belongs to Cardiovascular; Calcium gluconate belongs to Gastrointestinal Tract.
Why it happens
Increased extracellular calcium counteracts the cardiac depression caused by beta-blockade.
What to do
No routine action is needed for oral supplements. Monitor heart rate and blood pressure when calcium is given intravenously to a patient on bisoprolol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bisoprolol
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Bisoprolol with Calcium gluconate?
MediHelp rates the interaction as minor. Bisoprolol and Calcium gluconate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Intravenous calcium gluconate can transiently counteract the negative inotropic and chronotropic effects of bisoprolol. This is mainly relevant in beta-blocker toxicity, where calcium is used as a treatment.
How serious is the interaction between Bisoprolol and Calcium gluconate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for oral supplements. Monitor heart rate and blood pressure when calcium is given intravenously to a patient on bisoprolol.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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