Drug interactions
Bisoprolol + Clevidipine
Severity: Moderate
Bisoprolol and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so the combination can cause excessive hypotension. Beta-blockade may also blunt the reflex tachycardia that normally accompanies dihydropyridine vasodilation, and heart failure may worsen in susceptible patients.
What this interaction means in plain words
Bisoprolol and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Clevidipine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from arterial vasodilation with calcium channel blockade and beta-adrenergic blockade.
What to do
Titrate clevidipine to blood pressure with continuous monitoring. Watch heart rate and signs of heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Clevidipine
Frequently asked questions
Can I take Bisoprolol with Clevidipine?
MediHelp rates the interaction as moderate. Bisoprolol and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so the combination can cause excessive hypotension. Beta-blockade may also blunt the reflex tachycardia that normally accompanies dihydropyridine vasodilation, and heart failure may worsen in susceptible patients.
How serious is the interaction between Bisoprolol and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to blood pressure with continuous monitoring. Watch heart rate and signs of heart failure.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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