Drug interactions
Bisoprolol + Ephedrine
Severity: Moderate
Bisoprolol and Ephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bisoprolol blunts the beta-mediated cardiac and bronchodilator effects of ephedrine. Unopposed alpha stimulation may produce hypertension with reflex bradycardia.
What this interaction means in plain words
Bisoprolol and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Ephedrine belongs to Cardiovascular.
Why it happens
Beta-1 blockade antagonizes ephedrine's sympathomimetic activity, leaving alpha-mediated vasoconstriction unopposed.
What to do
Monitor blood pressure and heart rate when ephedrine is used. Choose an alternative to ephedrine for bronchospasm.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Bisoprolol with Ephedrine?
MediHelp rates the interaction as moderate. Bisoprolol and Ephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bisoprolol blunts the beta-mediated cardiac and bronchodilator effects of ephedrine. Unopposed alpha stimulation may produce hypertension with reflex bradycardia.
How serious is the interaction between Bisoprolol and Ephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when ephedrine is used. Choose an alternative to ephedrine for bronchospasm.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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