Drug interactions
Ephedrine + Rasagiline
Severity: Contraindicated
Ephedrine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine releases norepinephrine and its pressor effect can be strongly potentiated by MAO inhibitors. This risks a hypertensive crisis.
What this interaction means in plain words
Ephedrine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition increases neuronal norepinephrine stores and reduces metabolism, amplifying indirect sympathomimetic action of ephedrine.
What to do
Avoid ephedrine in patients on rasagiline. If a vasopressor is required in the perioperative setting, use a cautiously titrated direct-acting agent with close blood pressure monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ephedrine and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
- Caffeine + Ephedrine Major
Frequently asked questions
Can I take Ephedrine with Rasagiline?
MediHelp rates the interaction as contraindicated. Ephedrine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases norepinephrine and its pressor effect can be strongly potentiated by MAO inhibitors. This risks a hypertensive crisis.
How serious is the interaction between Ephedrine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine in patients on rasagiline. If a vasopressor is required in the perioperative setting, use a cautiously titrated direct-acting agent with close blood pressure monitoring.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
