Drug interactions
Ephedrine + Procarbazine
Severity: Contraindicated
Ephedrine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ephedrine releases noradrenaline indirectly, and procarbazine inhibits MAO, so the pressor response may be markedly exaggerated. This may cause a hypertensive crisis, severe headache, and arrhythmias.
What this interaction means in plain words
Ephedrine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ephedrine belongs to Cardiovascular; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition increases neuronal noradrenaline stores and prolongs the effect of indirect sympathomimetics.
What to do
Avoid ephedrine and other sympathomimetics during and for 14 days after procarbazine. Use non-pressor alternatives for symptom relief.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Ephedrine
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
- Caffeine + Ephedrine Major
Frequently asked questions
Can I take Ephedrine with Procarbazine?
MediHelp rates the interaction as contraindicated. Ephedrine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases noradrenaline indirectly, and procarbazine inhibits MAO, so the pressor response may be markedly exaggerated. This may cause a hypertensive crisis, severe headache, and arrhythmias.
How serious is the interaction between Ephedrine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine and other sympathomimetics during and for 14 days after procarbazine. Use non-pressor alternatives for symptom relief.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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