Drug interactions
Bisoprolol + Ivabradine
Severity: Moderate
Bisoprolol and Ivabradine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower heart rate, so combining them raises the risk of significant bradycardia, and rarely AV block. The combination is used in heart failure, but heart rate must be watched.
What this interaction means in plain words
Bisoprolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Ivabradine belongs to Cardiovascular.
Why it happens
Additive heart rate reduction from beta-1 blockade and inhibition of the sinus node If current.
What to do
Monitor heart rate and symptoms during initiation and up-titration. Reduce the ivabradine dose or stop it if resting heart rate falls persistently below the labeled threshold or symptomatic bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Frequently asked questions
Can I take Bisoprolol with Ivabradine?
MediHelp rates the interaction as moderate. Bisoprolol and Ivabradine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower heart rate, so combining them raises the risk of significant bradycardia, and rarely AV block. The combination is used in heart failure, but heart rate must be watched.
How serious is the interaction between Bisoprolol and Ivabradine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and symptoms during initiation and up-titration. Reduce the ivabradine dose or stop it if resting heart rate falls persistently below the labeled threshold or symptomatic bradycardia occurs.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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