Drug interactions
Bisoprolol + Losartan
Severity: Moderate
Bisoprolol and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination gives additive blood pressure lowering that may cause symptomatic hypotension, particularly at initiation. Losartan is fetotoxic in pregnancy.
What this interaction means in plain words
Bisoprolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from beta-blockade and angiotensin II receptor blockade.
What to do
Monitor blood pressure and heart rate when starting or adjusting doses, and stop losartan if pregnancy is confirmed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Bisoprolol with Losartan?
MediHelp rates the interaction as moderate. Bisoprolol and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination gives additive blood pressure lowering that may cause symptomatic hypotension, particularly at initiation. Losartan is fetotoxic in pregnancy.
How serious is the interaction between Bisoprolol and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting doses, and stop losartan if pregnancy is confirmed.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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