Drug interactions
Bisoprolol + Lurasidone
Severity: Moderate
Bisoprolol and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone has alpha-1 blocking properties that can cause orthostatic hypotension, which may add to the blood pressure lowering of bisoprolol. Dizziness and syncope are possible, especially at initiation or dose increases.
What this interaction means in plain words
Bisoprolol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Lurasidone belongs to Central Nervous System.
Why it happens
Additive hypotension from antipsychotic alpha-1 adrenergic antagonism and beta-blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone, and reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Bisoprolol with Lurasidone?
MediHelp rates the interaction as moderate. Bisoprolol and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone has alpha-1 blocking properties that can cause orthostatic hypotension, which may add to the blood pressure lowering of bisoprolol. Dizziness and syncope are possible, especially at initiation or dose increases.
How serious is the interaction between Bisoprolol and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or titrating lurasidone, and reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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