Drug interactions
Bisoprolol + Mefloquine
Severity: Moderate
Bisoprolol and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine can slow heart rate and cardiac conduction, and bisoprolol has similar effects. Using both may increase the risk of bradycardia or atrioventricular block.
What this interaction means in plain words
Bisoprolol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive pharmacodynamic effects on heart rate and atrioventricular conduction.
What to do
Monitor heart rate and ECG, especially at initiation. Avoid in patients with significant conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Mefloquine?
MediHelp rates the interaction as moderate. Bisoprolol and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine can slow heart rate and cardiac conduction, and bisoprolol has similar effects. Using both may increase the risk of bradycardia or atrioventricular block.
How serious is the interaction between Bisoprolol and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially at initiation. Avoid in patients with significant conduction disease.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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