Drug interactions
Bisoprolol + Nisoldipine
Severity: Moderate
Bisoprolol and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with a dihydropyridine calcium channel blocker produces additive blood pressure lowering. Hypotension and, occasionally, worsening heart failure can occur, particularly in patients with left ventricular dysfunction.
What this interaction means in plain words
Bisoprolol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Nisoldipine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: peripheral vasodilation from nisoldipine plus negative inotropic and chronotropic effects of bisoprolol.
What to do
Monitor blood pressure and heart rate when starting or adjusting either drug. Titrate doses gradually and watch for signs of heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bisoprolol
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Bisoprolol with Nisoldipine?
MediHelp rates the interaction as moderate. Bisoprolol and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a beta-blocker with a dihydropyridine calcium channel blocker produces additive blood pressure lowering. Hypotension and, occasionally, worsening heart failure can occur, particularly in patients with left ventricular dysfunction.
How serious is the interaction between Bisoprolol and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting either drug. Titrate doses gradually and watch for signs of heart failure.
What other medicines interact with Bisoprolol?
MediHelp also lists interactions of Bisoprolol with, for example, Aldesleukin, Amifostine, Amiodarone. The full list is on the Bisoprolol page.
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