Drug interactions
Bisoprolol + Tizanidine
Severity: Moderate
Bisoprolol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine and bisoprolol each lower blood pressure and heart rate, so combining them can cause additive hypotension and bradycardia. Dizziness and syncope are the main concerns.
What this interaction means in plain words
Bisoprolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bisoprolol belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive hypotensive and bradycardic effects from central alpha-2 agonism and beta-1 blockade.
What to do
Monitor blood pressure and heart rate during initiation and dose changes, adjusting doses if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Bisoprolol
Frequently asked questions
Can I take Bisoprolol with Tizanidine?
MediHelp rates the interaction as moderate. Bisoprolol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine and bisoprolol each lower blood pressure and heart rate, so combining them can cause additive hypotension and bradycardia. Dizziness and syncope are the main concerns.
How serious is the interaction between Bisoprolol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during initiation and dose changes, adjusting doses if symptomatic.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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