Drug interactions
Bitter melon + Hydrochlorothiazide-lisinopril
Severity: Minor
Bitter melon and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bitter melon may lower blood glucose and has been suggested to have mild diuretic or potassium-affecting properties. Combined with a thiazide, additive electrolyte disturbance is theoretically possible, but clinical evidence is scarce.
What this interaction means in plain words
Bitter melon and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive pharmacodynamic effects on glucose and electrolytes; the mechanism is not well established.
What to do
Check serum potassium and glucose if the herb is used regularly alongside the combination product, particularly in diabetic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Bitter melon with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Bitter melon and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bitter melon may lower blood glucose and has been suggested to have mild diuretic or potassium-affecting properties. Combined with a thiazide, additive electrolyte disturbance is theoretically possible, but clinical evidence is scarce.
How serious is the interaction between Bitter melon and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and glucose if the herb is used regularly alongside the combination product, particularly in diabetic patients.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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