Drug interactions
Bivalirudin + Gemcitabine
Severity: Moderate
Bivalirudin and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine-induced thrombocytopenia may add to the anticoagulant effect of bivalirudin and raise the likelihood of bleeding.
What this interaction means in plain words
Bivalirudin and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive bleeding risk from thrombocytopenia and direct thrombin inhibition.
What to do
Check platelet counts before and during therapy and monitor for bleeding. Adjust or hold the anticoagulant if thrombocytopenia becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Bivalirudin with Gemcitabine?
MediHelp rates the interaction as moderate. Bivalirudin and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine-induced thrombocytopenia may add to the anticoagulant effect of bivalirudin and raise the likelihood of bleeding.
How serious is the interaction between Bivalirudin and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check platelet counts before and during therapy and monitor for bleeding. Adjust or hold the anticoagulant if thrombocytopenia becomes significant.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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