Drug interactions
Bleomycin + Cholera vaccine
Severity: Moderate
Bleomycin and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bleomycin-based chemotherapy can suppress immune function and may reduce the response to cholera vaccine. Protection may be inadequate, and live-attenuated vaccines carry added infection risk.
What this interaction means in plain words
Bleomycin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression impairs vaccine-induced immune response.
What to do
Vaccinate at least 2 weeks before chemotherapy when possible, or after immune recovery. Avoid live vaccines during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Dengue vaccine Major
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Ethotoin Moderate
Frequently asked questions
Can I take Bleomycin with Cholera vaccine?
MediHelp rates the interaction as moderate. Bleomycin and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bleomycin-based chemotherapy can suppress immune function and may reduce the response to cholera vaccine. Protection may be inadequate, and live-attenuated vaccines carry added infection risk.
How serious is the interaction between Bleomycin and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy when possible, or after immune recovery. Avoid live vaccines during treatment.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
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