Drug interactions
Bleomycin + Dengue vaccine
Severity: Major
Bleomycin and Dengue vaccine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is live attenuated, and cytotoxic chemotherapy can weaken immune control of the vaccine virus. This may cause vaccine-related infection and a poor immune response.
What this interaction means in plain words
Bleomycin and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs vaccine response and permits replication of live vaccine virus.
What to do
Avoid live vaccines during chemotherapy and defer until immune recovery per local guidance. Obtain specialist advice if vaccination is urgently needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bleomycin and Dengue vaccine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Bleomycin
- Adenovirus types 4 and 7 live + Bleomycin Contraindicated
- Bleomycin + Brentuximab Contraindicated
- Bleomycin + Brentuximab vedotin Contraindicated
- Bleomycin + Trastuzumab deruxtecan Major
- Bleomycin + Cholera vaccine Moderate
- Bleomycin + Ethotoin Moderate
Frequently asked questions
Can I take Bleomycin with Dengue vaccine?
MediHelp rates the interaction as major. Bleomycin and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is live attenuated, and cytotoxic chemotherapy can weaken immune control of the vaccine virus. This may cause vaccine-related infection and a poor immune response.
How serious is the interaction between Bleomycin and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and defer until immune recovery per local guidance. Obtain specialist advice if vaccination is urgently needed.
What other medicines interact with Bleomycin?
MediHelp also lists interactions of Bleomycin with, for example, Adenovirus types 4 and 7 live, Brentuximab, Brentuximab vedotin. The full list is on the Bleomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
