Drug interactions
Blinatumomab + Trastuzumab
Severity: Moderate
Blinatumomab and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blinatumomab causes cytokine release, neurotoxicity, neutropenia and infections, while trastuzumab with chemotherapy can add neutropenia. Combined use is unusual since they treat different malignancies, so the additive risk is mostly theoretical.
What this interaction means in plain words
Blinatumomab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression and immune effects, mainly from blinatumomab T-cell engagement.
What to do
Monitor blood counts, infection signs and neurologic status during therapy, and manage neutropenia per blinatumomab labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Other interactions of Blinatumomab
- Blinatumomab + Carbamazepine Moderate
- Blinatumomab + Cyclosporin Moderate
- Blinatumomab + Ethosuximide Moderate
- Blinatumomab + Phenytoin Moderate
- Blinatumomab + Quinidine Moderate
- Blinatumomab + Quinine Moderate
Frequently asked questions
Can I take Blinatumomab with Trastuzumab?
MediHelp rates the interaction as moderate. Blinatumomab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes cytokine release, neurotoxicity, neutropenia and infections, while trastuzumab with chemotherapy can add neutropenia. Combined use is unusual since they treat different malignancies, so the additive risk is mostly theoretical.
How serious is the interaction between Blinatumomab and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, infection signs and neurologic status during therapy, and manage neutropenia per blinatumomab labeling.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
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