Drug interactions
Bortezomib + Butabarbital
Severity: Moderate
Bortezomib and Butabarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butabarbital is a barbiturate that induces CYP3A4 and may lower bortezomib exposure. This could reduce anti-myeloma efficacy.
What this interaction means in plain words
Bortezomib and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4-mediated bortezomib metabolism.
What to do
Avoid long-term use of barbiturates where possible. If unavoidable, monitor disease response and consider alternatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bortezomib
- Apalutamide + Bortezomib Major
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
Frequently asked questions
Can I take Bortezomib with Butabarbital?
MediHelp rates the interaction as moderate. Bortezomib and Butabarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butabarbital is a barbiturate that induces CYP3A4 and may lower bortezomib exposure. This could reduce anti-myeloma efficacy.
How serious is the interaction between Bortezomib and Butabarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term use of barbiturates where possible. If unavoidable, monitor disease response and consider alternatives.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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