Drug interactions
Apalutamide + Bortezomib
Severity: Major
Apalutamide and Bortezomib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce bortezomib exposure through induction of CYP3A4 and CYP2C19, potentially weakening antimyeloma activity.
What this interaction means in plain words
Apalutamide and Bortezomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Bortezomib belongs to Oncology.
Why it happens
Induction of CYP3A4 and CYP2C19 increases bortezomib metabolism.
What to do
Avoid combination with strong CYP3A4 inducers when possible and monitor for reduced response if coadministered.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Bortezomib
- Bortezomib + Carbamazepine Major
- Bortezomib + Etrasimod Major
- Bortezomib + Fosphenytoin Major
- Bortezomib + Idelalisib Major
- Bortezomib + Lonafarnib Major
- Bortezomib + Mitotane Major
Frequently asked questions
Can I take Apalutamide with Bortezomib?
MediHelp rates the interaction as major. Apalutamide and Bortezomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may reduce bortezomib exposure through induction of CYP3A4 and CYP2C19, potentially weakening antimyeloma activity.
How serious is the interaction between Apalutamide and Bortezomib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination with strong CYP3A4 inducers when possible and monitor for reduced response if coadministered.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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